Title of funded project：Dipeptide-based chirality-responsive polymer: Design and application in chiral separation

Funding agency：National Natural Science Foundation of China

Grant number：51473131

Total funding amount：CNY 840,000

Chiral chromatography is critical for analysis and separation of chiral intermediate and drugs. It also largely promote the development of modern medicine and chirality-related applications. In this research, developing highly efficient chiral chromatographic stationary phase is the critical step for this research. However, most of products are created by foreign companies, the products with indepeendent intellectual propertyare quite rare in domestic field. On the other hand, these commerical products have many shortcomings and invidently occur many problems, such as poor selectivity and versatility, low separation effeciency and loading effeciency, as well as high synthesis costs. Thus, developing new generation of chiral chromatographic separation materials to satisiy the increasingly demand of market is quite urgent.

In this project, chirality-repsonisve polymers based on dipeptides are introduced to the design of chiral chromatographic stationary phase. In this system, chiral interaction will induce obvious change in the conformation and functions of polymer chains. This will help to evidently improve the separation efficiency of materials. Taking advantages of smart polymer and nanotechnology, novel responsive nano chiral separation materials will be developed. Compared with the traditional materials, the developing materials can be used in a wide range of chiral speciess with high loading efficiency. In addition, dynamic separation process can be modulated intelligiently due to the smart feartures of polymer materials, which will bring obvious merits for further design. We believe this technology will have wide application perspective, and will help to construct novel chiral separation products with independent intellectual property.