我组（18T7）在仿生可调控离子通道方面取得新进展。人类的感知与众多的离子通道密不可分，而钠通道就是其中一个重要的离子通道。以唾液酸为末端的糖链在钠通道表面普遍存在，它可以诱导通道表面去极化，从而为钠通道的打开和关闭（即 "ON"和 "OFF"）贡献一种调节机制。然而，开发人工离子通道并实现精确调控仍然是一项具有挑战性的任务。在这项工作中，展示了一种功能性聚合物修饰的离子纳米通道。利用智能聚合物从收缩状态到膨胀状态的构象变化，该通道在离子流经纳米通道时显示出唾液酸响应性的 "ON"与 "OFF"调节。此外，聚合物对不同的唾液酸有不同的相互作用，使得纳米通道实现对唾液酸的高度选择性和灵敏性识别。这项工作为理解生物离子通道的调节提供了一个仿生学的视角，同时本工作也提出了在分析唾液酸和唾液酸化糖以及捕捉转移性肿瘤细胞方面的应用场景。

相关成果发表在《先进材料界面》Advanced Materials Interfaces，第一作者是18T7组博士研究生逯文启。以上研究工作得到国家自然科学基金项目、我所创新特区组启动基金、兴辽英才计划等项目的支持。

Bioinspired Sialic Acid Regulated Ion Nanochannel

Wenqi Lu, Minmin Li, Yuting Xiong, Wenjing Sun, Hang Yang, Haijuan Qin, Jie Xiao, Fusheng Zhang, Mengyuan Song, Xue Wang, and Guangyan Qing*

Adv. Mater. Interfaces 2022, 2200186.  DOI: 10.1002/admi.202200186.

Human perception is inextricably linked to numerous ion channels, and sodium channel is one of the important ion channels. Sialic acidterminated glycan chains are commonly found on the surface of the sodium channel, which can induce the channel surface depolarization and thus contribute a regulation mechanism for the closing and opening (i.e., “ON” and “OFF”) of the sodium channel. However, the development of artificial ion channel to achieve precise regulation remains a challenging task. In this work, taking advantage of the conformational change of smart polymer from a contracted state to a swollen one, a functional polymer-modified ion nanochannel is demonstrated that shows the free sialic acid-responsive “ON” to “OFF” regulation in ion flow through the nanochannel. Furthermore, the distinct recognition interactions of the polymer toward different sialic acids allow for the nanochannel to exhibit the highly selective and sensitive recognition of them. This work provides a biomimetic perspective to understand the regulation of biological ion channel, but also presents the application scenarios in the analysis of sialic acids and sialylated glycans, as well as the capture of metastatic tumor cells.