项目名称：基于二肽的手性响应性聚合物：设计及其在手性分离中的应用

项目来源：国家自然科学基金面上项目

项目编号：51473131

项目金额：84万元

手性色谱是应用于手性中间体、手性药物等的分离与分析的关键，在现代制药和手性相关应用中占据极其重要的地位，其核心是高性能手性色谱固定相的开发。现有产品都是国外公司的产品，在我国市场上尚无具有我国独立知识产权的产品出现。而且即使是这些产品，由于受材料的限制，在选择性、通用性、分离效率、柱效、上样量和成本等方面存在诸多问题。因此亟需开发新型的高性能的手性色谱分离材料，以满足日益增长的市场需求。

本课题创新地将基于二肽的手性响应性聚合物引入到手性色谱固定相的研发中，并与纳米技术结合，开发新型响应性纳米手性色谱固定相。相对于传统的手性色谱固定相，研制的材料适用于多种不同类型的手性分子，载药量大，可通过环境条件的改变对分离过程进行智能控制，因而可扩展性强，应用前景广阔，可以发展为具有我国独立知识产权的手性色谱分离技术和产品。

Title of funded project：Dipeptide-based chirality-responsive polymer: Design and application in chiral separation

Funding agency：National Natural Science Foundation of China

Grant number：51473131

Total funding amount：CNY 840,000

Chiral chromatography is critical for analysis and separation of chiral intermediate and drugs. It also largely promote the development of modern medicine and chirality-related applications. In this research, developing highly efficient chiral chromatographic stationary phase is the critical step for this research. However, most of products are created by foreign companies, the products with indepeendent intellectual propertyare quite rare in domestic field. On the other hand, these commerical products have many shortcomings and invidently occur many problems, such as poor selectivity and versatility, low separation effeciency and loading effeciency, as well as high synthesis costs. Thus, developing new generation of chiral chromatographic separation materials to satisiy the increasingly demand of market is quite urgent.

In this project, chirality-repsonisve polymers based on dipeptides are introduced to the design of chiral chromatographic stationary phase. In this system, chiral interaction will induce obvious change in the conformation and functions of polymer chains. This will help to evidently improve the separation efficiency of materials. Taking advantages of smart polymer and nanotechnology, novel responsive nano chiral separation materials will be developed. Compared with the traditional materials, the developing materials can be used in a wide range of chiral speciess with high loading efficiency. In addition, dynamic separation process can be modulated intelligiently due to the smart feartures of polymer materials, which will bring obvious merits for further design. We believe this technology will have wide application perspective, and will help to construct novel chiral separation products with independent intellectual property.