Wenqi Lu, Minmin Li, Yuting Xiong, Wenjing Sun, Hang Yang, Haijuan Qin, Jie Xiao, Fusheng Zhang, Mengyuan Song, Xue Wang, and Guangyan Qing*

Adv. Mater. Interfaces 2022, 9, 2200186.

Human perception is inextricably linked to numerous ion channels, and sodium channel is one of the important ion channels. Sialic acidterminated glycan chains are commonly found on the surface of the sodium channel, which can induce the channel surface depolarization and thus contribute a regulation mechanism for the closing and opening (i.e., “ON” and “OFF”) of the sodium channel. However, the development of artificial ion channel to achieve precise regulation remains a challenging task. In this work, taking advantage of the conformational change of smart polymer from a contracted state to a swollen one, a functional polymer-modified ion nanochannel is demonstrated that shows the free sialic acid-responsive “ON” to “OFF” regulation in ion flow through the nanochannel. Furthermore, the distinct recognition interactions of the polymer toward different sialic acids allow for the nanochannel to exhibit the highly selective and sensitive recognition of them. This work provides a biomimetic perspective to understand the regulation of biological ion channel, but also presents the application scenarios in the analysis of sialic acids and sialylated glycans, as well as the capture of metastatic tumor cells.