基于三肽的智能聚合物构象转变驱动的CAMP敏感纳米通道

  受生物纳米通道的启发，开发了一种基于三肽Arg-Thr-Ala（RTA）设计的新型环状3'，5'-单磷酸腺苷（cAMP）调控的人工纳米通道。 三肽和cAMP之间的高度特异性结合会触发智能聚合物链从收缩状态到溶胀状态的明显构象转变，从而动态调节纳米通道的门控行为。

CAMP sensitive nanochannels driven by conformational transition of a tripeptide-based smart polymer

Shengyan Ji, Yuting Xiong, Wenqi Lu, Minmin Li, Xue Wang, Cunli Wang, Dongdong Wang, Jie Xiao, Zhichao Zhu, Lihua Chen, Yahui Zhang^* and Guangyan Qing^*

Chem. Commun., 2020, 10.1039/c9cc09588h.

  Inspired by biological nanochannels, a novel cyclic 3’,5’-adenosine monophosphate (cAMP)–regulated artificial nanochannel based on a tripeptide Arg-Thr-Ala (RTA) design is developed. Highly specific binding between the tripeptide and cAMP triggers an obvious conformational transition of a smart polymer chain from a contracted state to a swollen one, which leads to a dynamic modulation of the gating behaviours of the nanochannels.